The COVID-19 Protein Portal is a UK initiative, supported by UK funding bodies for research within UK universities and research institutes. Scientists working outside the UK would be ineligible to receive proteins through current funding.
The UK COVID-19 Protein Portal is set up by funding bodies to serve UK-based scientists, however there may be an opportunity to extend or duplicate this initiative for other countries.
The COVID-19 Protein Production Consortium provides the proteins free of charge to UK-based scientists, for non-commercial research projects of scientific merit, with the requirement that results will be shared rapidly and openly with the consortium and made publicly available, in line with the Wellcome open data statement
Leading UK protein production research groups are providing time and reagents in-kind, as part of collaborative COVID-19 research efforts, with agreement from their respective funders. UK research groups additionally interested in contributing reagents to the portal should consult with their funder prior to making commitments.
Yes, the laboratories producing proteins are active during the lockdown period, due to the essential services that they provide. All laboratory staff are carefully adhering to health and safety guidelines, including social distancing.
The COVID-19 Protein Production Consortium (CPPC) will endeavour to meet demand for protein reagents, where scientifically justified. Users are advised to request the minimum amount of protein required for their experiments, bearing in mind that others will also be submitting requests. When submitting a request for a reagent, users are asked to describe the intended use of the protein, which will help the CPPC to understand how much is required. Supply of reagents is anticipated for primary research activities; large scale or manufacturing efforts are not appropriate for this mechanism.
Additional reagents are being added to the database regularly. Please contact us if you are seeking a specific protein or reagent that is not listed.
It is not possible to request protein from a particular laboratory; your request will be allocated to an expert protein production laboratory based on available capacity.
Research proposals enable the COVID-19 Protein Production Consortium to prioritise and coordinate reagent allocation based on scientific merit, impact and how urgently they are required.
The scientific case required is brief, with information requested to justify your request for reagents and demonstrate the rationale and feasibility of your approach. You will have an opportunity to upload supporting information, such as publications or data.
Reagents will be sent by courier to the UK laboratory address specified on your online research proposal form, under appropriate conditions specific for the reagent. Shipping costs will be covered by the protein provider, unless otherwise agreed.
Laboratories offering proteins through the COVID-19 Protein Portal are committed to providing reagents as quickly as possible. When a request is submitted, scientific review and allocation to a protein provider should be completed within one week. The time taken to receive reagents after approval will vary depending on the availability of the protein and the delivery time.
No, the reagents offered free of charge through the COVID-19 Protein Portal can only be used for non-commercial, research purposes. The portal is anticipated to support key primary research; larger scale activities would be better suited to industry independently. However, queries are welcome to the COVID-19 Protein Production Consortium, please contact us.
In the spirit of Open Science, it is a requirement that all data from experiments using proteins from the COVID-19 Protein Portal will be published to public data repositories and peer reviewed journals in a timely manner, in line with the Wellcome open data statement
To maximise the value of the resource and enable research to progress faster, we expect researchers to share back their preliminary research findings and technical information that may be relevant for other researchers working with the same reagents. We also strongly encourage sharing back negative findings (e.g. assay and buffer conditions that are not optimal). Sharing data and expertise in a collaborative way will enable research to progress faster, translating into therapeutics and rapid public health impacts.
All publications should acknowledge the source of reagents obtained through the COVID-19 Protein Portal, with the following text “Protein [X] was provided by the UK COVID-19 Protein Production Consortium”. Where there is likely to be significant scientific contribution by the protein provider, we advise that any discussions about collaboration and potential authorship happen early on.
UK Laboratories with expertise in protein production are warmly invited to join the COVID-19 Protein Production Consortium (CPPC). Please contact us to send an expression of interest to the CPPC. You are encouraged to engage with your research funder in advance.
Please contact us if you have any other questions.